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Rheumatoid Arthritis!?

More and more people are beginning to turn to CBD as an added supplementation to help RA symptoms and pain. So what it RA?..... 

"Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels."  

The problem with RA is that it is an autoimmune disorder and is the result of our immune system mistakenly attacking our own body's tissues.  Some people believe vaccines play a role in the development of autoimmune diseases such as RA over time as a vaccine's main role is to supercharge our immune system to fight off disease, not kill the disease directly.

RA actually is a bit different than Osteoarthritis which causes wear and tear damage.  RA actually affects the lining of our joints resulting in painful swelling that leads to bone erosion and joint deformity, just like the featured photo of this post shows.

Inflammation associated with rheumatoid arthritis is the main culprit that leads to the damage of other parts of the body as well. Even though new medications are improving treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.  Cytokines (secreted cellular proteins) play a big role in this over active inflammation.

Cytokines and Inflammation?

"Cytokines are small secreted proteins released by cells that have a specific effect on the interactions and communications between cells. There are both pro-inflammatory cytokines and anti-inflammatory cytokines. There is significant evidence showing that certain cytokines/chemokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons. Certain inflammatory cytokines are also involved in nerve-injury/inflammation-induced central sensitization, and are related to the development of contralateral hyperalgesia/allodynia."

CBD’s Role?

Although studies still lack solid results of the efficacy of using Cannabinoids, the number of people and patients turning to CBD is increasing in numbers. CBD studies are beginning to show anti-inflammatory effects by activating the receptors (CB2) which decrease cytokine production and immune cell mobilization.

"In contrast, cannabinoid type 1 receptor (CB1) activation on immune cells is proinflammatory while CB1 antagonism provides anti-inflammatory effects by increasing β2-adrenergic signaling in the joint and secondary lymphoid organs."

Remember CB2 Receptors are mostly found in tissue/organs, and CB1 Receptors are mainly found in the nervous system and brain.

Please note that CBD is without psychotropic effects and has very few side effects if any. CBD has demonstrated antiarthritic effects independent of cannabinoid receptors. In addition to controlling inflammation, cannabinoids have shown in studies to help reduce pain by activating the CB1 receptors in our central nervous system.

"Summary: Cannabinoids might be a suitable treatment for RA, but it is important to target the right receptors in the right place. For clinical studies, we propose a combination of a CB2 agonist to decrease cytokine production, a peripheral CB1 antagonist to prevent detrimental CB1 signaling and to support anti-inflammatory effects of CB2 via activation of β2-adrenergic receptors and CBD to induce cannabinoid-receptor-independent anti-inflammatory effects."

 

Sources:

https://pubmed.ncbi.nlm.nih.gov/30920973/

https://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/symptoms-causes/syc-20353648

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000161/

https://www.labroots.com

 

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