ENDOCANNABINOID SYSTEM - PART 2 OF 2

CB 2 receptors – What are they?

In part 1 of this blog we touched briefly on our Endocannabinoid CB1 receptors located mostly in the brain and central nervous system as well as their effects on anxiety and depression.

CB2 receptors are also a big part of the Endocannabinoid system primarily associated with our immune system.

Where are CB2 receptors found in the body?

CB2 receptors are mostly found outside of the brain, commonly appearing in our organs and skeletal system:

  • Gastrointestinal System
  • Spleen
  • Liver
  • Heart
  • Kidneys
  • Bones
  • Blood Vessels
  • Lymph Cells
  • Endocrine Glands
  • Reproductive Organs

Commonly referred to as the peripheral receptor for cannabinoids. Abundant in immune tissue, research is looking at its possible immune function role, especially its ability to inhibit inflammation.

Immune System Modulation?

CBD’s role is to help stimulate these CB2 receptors and bring the system back into balance.  Research shows it may provide autoimmune disease benefits in the following ways.

  • Modulation of the immune system
  • Decreasing general inflammation
  • Helping to assist the digestive system.

By having the ability to inhibit inflammation and balance or modulate the immune system by triggering these CB2 receptors, research is also looking at how it may help treat symptoms for the following inflammatory autoimmune diseases. 

  • ALS
  • Rheumatoid Arthritis
  • Ulcerative Colitis
  • Crohn’s disease
  • Fibromyalgia
  • Huntington’s disease
  • MS

Cytokines and CBD?

Simply put they are proteins secreted by the immune system, signaling molecules that mediate and regulate immunity and inflammation.  CBD seems to work by stimulating the CB2 receptors to suppress immune responses by inhibiting production of pro-inflammatory cytokines and boost anti-inflammatory cytokines.  Thus, creating a balance. Promising research is finding that CBD may even have an effect on T-Cell production to help suppress the immune system memory which will help reduce the number of future autoimmune attacks. We have mentioned that we believe CBD’s effects are accumulative…the more you use it the better it works.

People are making plenty of claims about how they are benefiting from CBD.  CBD seems to help decrease chronic pain, inflammation, and spasms associated with some of these conditions.  Testimonials are popping up all over the web.

Quote: “There have been few specific investigations on cannabinoid treatment for AI, due to federal prohibition on human clinical trials. However, extensive studies in test-tubes and in animals have reported the anti-inflammatory benefits of cannabinoids for specific AI conditions like multiple sclerosis and rheumatoid arthritis. Cannabis and other adaptogenic herbs are known to be immune modulating. They act as a regulating tool: they can bring an over or under-reacting immune system back into balance. However, the difference between "immune modulating" and "immune boosting" can be tricky to decipher. It is generally felt that someone with autoimmunity would not want to take anything which boosts the immune system, but this is a point of contention among practitioners.” Source

Inflammation is key!

Since inflammation is a major underlying cause of many illnesses including auto immune disease and CBD is showing great promise to help reduce and or regulate the bodies immune response by inhibiting inflammation, it may be less likely the body will induce a full-blown autoimmune response.  Research on animal models of multiple sclerosis show that cannabinoids decreased the gene transcription that promoted inflammation. 

Quote: “Despite a scarcity of specific human based studies, patients with autoimmune disorders have been able to improve their situation by integrating cannabis medicine into their lifestyle. Dr. Bonni Goldstein has seen a number of patients with lupus and rheumatoid arthritis wean off pharmaceuticals and control their symptoms with cannabis, dietary changes, exercise, and stress reduction. Goldstein gave the example of a young patient with ankylosing spondylitis (spine disease). Goldstein reported that after two months on cannabis the patient discontinued three of the pharmaceuticals, experienced a significant improvement in her pain symptoms, and was "able to participate in her life again". Dr. Goldstein encourages patients to try various CBD/THC ratios, and to experiment with raw cannabinoids such as THCA and CBDA. Trial and error is required to find what works best for an individual's unique situation.” Source

Terpenes found in Full Spectrum CBD oil are being studied as well. Known to decrease inflammation through their ability to stimulate the CB2 receptor.  Source

  • Beta-Caryophyllene
  • Myrcene

Does CBD help with Inflammation?

We can only attest personally to our own experience. Yes!  With regular CBD intake of approximately 30mg to 50mg per day we have experienced reduced gastrointestinal and joint inflammation, eating and long walks are much more enjoyable.  Along with that, anxiety has been significantly reduced as well as highly improved sleeping patterns.  In hopes others comment on this blog, we really would love to hear other testimonials so we can share with the world.

SOURCES:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075023/

https://www.fundacion-canna.es/en/molecular-mimicry-role-cannabis-healing-autoimmune-disease?fbclid=IwAR0Jc_mpHbwx2SeKW7ZLwVJmaLtRx_cqudNBAij1X3fP7ATxYMb56u_csJo

https://www.sciencedirect.com/topics/neuroscience/cb2-receptor-agonist

https://www.sciencedirect.com/topics/neuroscience/cannabinoid-receptor-type-2

https://www.frontiersin.org/articles/10.3389/fnins.2016.00321/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

 

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