CBD and SCHIZOPHRENIA?
First of all, let’s get the Hollywood misinformation and negative portrayals of schizophrenia in contemporary movies out of our heads. Erase the memories of Leonardo DiCaprio in the movie Shutter Island……
Schizophrenia is a disease that is growing in numbers and affects millions now.
Quote: “Worldwide about 1 percent of the population is diagnosed with schizophrenia, and approximately 1.2% of Americans (3.2 million) have the disorder. About 1.5 million people will be diagnosed with schizophrenia this year around the world. In the United States, this means about 100,000 people will be diagnosed, which translates to 7.2 people per 1,000 or about 21,000 people within a city of 3 million who are likely to be suffering from schizophrenia.”
Causes and Symptoms?
The cause of schizophrenia is still unknown, but the main suspects are genetics, brain chemistry, and environmental toxins or physical trauma. Neurotransmitters called dopamine and glutamate, may contribute to schizophrenia.
Symptoms may include:
Cognition (thoughts) usually becomes delusional and are often accompanied by hallucinations and disorganized speech. An impaired ability to function can affect behavior and emotions that sometimes lead to psychotic breakdowns.
- False beliefs that are not based in reality.
- Seeing or hearing things that don't exist with the full force and impact as them being real.
- Disorganized thinking (speech).
- Extremely disorganized or abnormal motor behavior.
- Negative symptoms. Reduced or lack of ability to function normally.
“In men, schizophrenia symptoms typically start in the early to mid-20s. In women, symptoms typically begin in the late 20s. It's uncommon for children to be diagnosed with schizophrenia and rare for those older than age 45.”
Can CBD help?
Name of documented source:
A critical review of the anti-psychotic effects of cannabidiol: 30 years of a translational investigation.
First, we would like to digress for a moment: The fact they have known about and have been studying CBD’s effects on this disease for 30 years and not telling us should piss you off, but that’s another conversation.
To summarize this journal source as briefly as possible, CBD shows promise, when administered chronically. Positive results and Negative results have both occurred. Some patients with drug resistance seem to have the worst or negative results while other patients see improvements. Acute doses from our review of many points in the article don’t seem to have the same effects as chronic or long-term CBD regimens. We encourage people with this disease to read this in its entirety and look at all the other studies listed in the tables. Unfortunately, we cannot comment any more on this article due to copyright issues. So, we will use the fair use right laws to make a couple of quotes to get you started.
Here are some quotes:
“EVIDENCE FROM CLINICAL TRIALS - For ethical reasons, the first clinical trials with CBD were open labeled and with a small number of patients. The first one was a case-study with a 19-year old female patient with schizophrenia. The rationale of the trial was the presence of serious side effects the patient was experiencing with previous antipsychotic drugs. After hospitalization and a wash-out period of four days the patient was treated for four weeks with increasing doses of CBD up to 1,500 mg/day. Then this treatment was replaced by placebo for four days followed by haloperidol treatment at increasing doses up to 12.5 mg/day. CBD treatment significantly reduced the scores of the Brief Psychiatric Rating Scales (BPRS). Unfortunately, symptoms worsened when CBD was suspended. Haloperidol decreased BPRS scores, but not beyond the levels reached with CBD .”
“Taken together, and even considering some conflicting results, preclinical data indicate that CBD does possess antipsychotic properties, having a profile compatible with atypical antipsychotics. Consistent with this suggestion, studies investigating changes in the expression of the proto-oncogene c-Fos showed that both CBD and clozapine, but not haloperidol, are able to increase this expression in the prefrontal cortex, while only haloperidol enhanced c-Fos expression in the dorsal striatum [10, 11].”
Taken together, the results discussed above clearly indicate that CBD behaves in preclinical and clinical studies as an atypical antipsychotic, improving psychotic-like symptoms in doses that do not impair motor function. The mechanisms of these properties, however, are still not completely understood. One possibility, put forward in the present review (Fig. 2), is that they depend on direct (TRPV1 agonism) and indirect (increase in anandamide-mediated CB1 activation, causing a decrease in GABA release) facilitation of glutamate activity in the prefrontal cortex. Even considering that it is an oversimplification, since it does not take into account other possible CBD mechanisms, we hope the hypothesis will have enough heuristic value to inspire new studies. Considering the need for new and effective antipsychotic and the remarkable safety profile of this compound, these studies will be most welcome.”
Main Source: https://www.ncbi.nlm.nih.gov/pubmed/22716160
(FREE PDF) Full Journal Download here: https://doi.org/10.2174/138161212802884681
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