CBD and Psoriasis?
We have discussed the Endocannabinoid System and CBD’s effects or stimulation of it. We have also established that CBD does have anti-inflammatory and immune suppression properties. This is no longer speculation as there is lots of research that proves this. Here is just one of many article sources that support this data. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
Ok, so what is Psoriasis?
Psoriasis, an auto-immune disease that comes along with a lot of inflammation and some pain. The cause is thought to be with T cells and other white blood cells, called neutrophils, in your body. They are your bodies defense mechanism against viruses and bacteria mostly. Some where along the line, this defense system gets miss-programmed and attacks good cells. This attack on good cells triggers a rapid increase in the production of new skin cells, T cells, and more neutrophils (called keratinocyte hyper-proliferation), that travel into the skin and can cause pustular lesions, redness, and swollen inflamed itchy flaky skin. This rapid ongoing cycle of new skin cells moves to the outermost layer of skin in days rather than weeks causing a rapid build-up that leads to the common thick, scaly patches and red swollen skin, continuing until treatment stops the cycle. The exact cause is still unknown but genetic and environmental factors are the main suspects.
CBD and Keratinocyte Hyper-proliferation?
Keratinocytes are one of the predominant cells of the epidermis (basal layer), their main role is to produce keratin and form the epidermal water barrier layer of your skin by secreting lipids.
In our past articles we covered some basics about the endocannabinoid system along with CB1 and CB2 receptors. Well, these receptors are also found in the skin. Studies have now shown that cannabinoids can inhibit keratinocyte proliferation and support a potential role in the treatment of psoriasis.
“2.5.6. Selected Inflammatory Diseases: Psoriasis (PSO)
Psoriasis (PSO) is a chronic inflammatory skin disorder, often accompanied by additional non-cutaneous symptoms (e.g., arthritis), and its pathogenesis is still not fully understood. Indeed, genetic  and epigenetic  abnormalities, as well as alterations in the cutaneous microbiota , pH , or, most importantly, IL-17 signaling [251,252] are known to be involved in its development, and it is surely accompanied by a disturbance in the dynamic cross-talk between epidermal keratinocytes and professional cutaneous immune cells. This inappropriate communication then leads to pathological inflammatory processes and to a disturbance in the proliferation/differentiation balance of epidermal keratinocytes [249,253,254,255,256]. Since, as discussed above, proliferation/differentiation as well as immune activity of epidermal keratinocytes are under the tight control of the eCB signaling, it is not surprising that therapeutic exploitation of various cannabinoids in PSO has already been suggested by multiple authors [237,257,258,259,260,261].”
“122. Wilkinson J.D., Williamson E.M. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J. Dermatol. Sci. 2007;45:87–92. doi: 10.1016/j.jdermsci.2006.10.009. [PubMed] [CrossRef] [Google Scholar]”
If you are looking for natural, herbal, or holistic ways of supplementing your ailments, CBD is showing promise in many areas. CBD is often misunderstood and often called the miracle herb or a remedy for a 100 ailments. Try to remember, CBD really does only one thing, from all the research we have covered, the main effect CBD has is homeostatic, it modulates your CB Receptors. CBD doesn’t care what cells your CB receptors are attached to or what you are suffering from, it only see’s what CB receptors are out of whack and tries to bring them back to equilibrium. Your symptoms and ailments are simply a result of this imbalance, amongst other things. CBD simply steps in to fix the imbalance, not the disease, by modulating the receptors that are out of frequency with the body, organs, and mind. This is our hypothesis as we can not prove this through our own studies….but it makes sense.
If you have positive or negative results supplementing your Psoriasis with CBD please share so we can help others suffering from this learn more.
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