CBD & ANANDAMIDE “THE HAPPY CANNABINOID”

Anandamide?

It is a neurotransmitter and a CB1/CB2 cannabinoid-receptor binding agent naturally produced by the body on demand and is highly utilized by the brain in particular.  Its main role is to shift our bodies and mind into homeostasis.  Its biggest role is regulating mood, anxiety, fear, and now studies are showing it has an effect on ovulation and fetal development.   Unfortunately, Anandamides are extremely fragile and easily broken down in our bodies by protein enzymes which can lead to a cannabinoid deficiency.   To make things worse, some of us are genetically predisposed to having low Anandamide levels due to low production or an excess in the Fatty acid amide hydrolase (FAAH) & monoacylglycerol lipase (MAGL) enzymes that break down Anandamide causing low levels of this “JOY” molecule.  This of course can possibly perpetuate anxiety and depression indefinitely.

Quote: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

“Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes without showing the undesirable side effects of direct cannabinoid receptor agonists, indicating that FAAH may be a promising therapeutic target.”

CBD’s Role as an FAAH inhibitor

Research is starting to show that CBD interacts with or helps block the FAAH proteins to keep from degrading Anandamide, which leads to more support for CBD’s pharmacological effects for reducing anxiety, depression, inflammation, fear etc etc.  Reducing this breakdown of Anandamide in turn allows levels to stay high or increased making them readily available when the body is under stress and needs support for a homeostatic reset.  CBD also plays the role of filling in the CB1 and CB2 receptors when Anandamide is low which has been shown in research findings and many peoples claims to help reduce many of the mentioned ailments we have blogged about in recent articles.

Quote: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573017/

“Recent studies have investigated whether CBD interacts with proteins of the ‘endocannabinoid signalling system' other than the CB1/CB2 receptors. These proteins are: (i) fatty acid amide hydrolase (FAAH) (Cravatt et al., 1996), the intracellular enzyme catalysing the hydrolysis of the endogenous cannabinoid ligand, anandamide (arachidonoylethanolamide, AEA) (Ueda et al., 2000, for review); and (ii) the ‘anandamide membrane transporter' (AMT) (Di Marzo et al., 1994), which facilitates the transport of AEA across the cell membrane and, subsequently, its intracellular degradation (Hillard & Jarrahian, 2000, for review). It was found that CBD inhibits both AEA hydrolysis by FAAH-containing membrane preparations (Watanabe et al., 1996), and AEA uptake by RBL – 2H3 cells via the AMT (Rakhshan et al., 2000). Although these effects were observed at high μm concentrations, these findings raised the possibility that some of the pharmacological actions of CBD might be due to inhibition of AEA degradation, with subsequent enhancement of the endogenous levels of this mediator, for which neuroprotective (Hansen et al., 1998) and anti-inflammatory (Di Marzo et al., 2000a) properties have been previously suggested.”

The BIG QUESTION?

If our bodies produce this so-called natural cannabinoid Anandamide and our Cells in our bodies do in fact have cannabinoid receptors (CB1/CB2) … Are we deficient?  Are we malnourished?!  Will the government eventually tell us that CBD is an essential nutrient needed by the body, like Iron, Calcium, and other vitamins and minerals?  If we have this scientifically proven Endocannabinoid System and it isn’t fed properly, is this causing our ailments that so many of us live with and have accepted as simply a part life?

If you haven’t given CBD a try, we urge you to consult your physician and consider adding CBD to your dietary intake.  It may help.

Sources:

https://www.nature.com/articles/ncomms7395

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573017/

 

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